Pharmaceutical Grade Low Substituted-Hydroxypropyl Cellulose (L-HPC)

Uquick Low-substituted HydroxyPropylCellulose (L-HPC) doesn't dissolve in water. This filler material swells by absorbing water, leading to an increase in volume. This volumetric expansion facilitates quick disintegration of the tablet.

Pharmaceutical Grade Low Substituted-Hydroxypropyl Cellulose (L-HPC)

Low-Substituted Hydroxypropylcellulose (L-HPC) is a globally approved pharmaceutical excipient and food additive, primarily used as a tablet disintegrant and binder. It’s available in various grades as an odorless, white to yellowish-white powder. L-HPC from Landu Uquick, supplied by Azelis, is a cost-effective, high-performance choice for manufacturers.

Low-Substituted Hydroxypropylcellulose (L-HPC) is a non-ionic, multi-functional excipient. It’s derived from cellulose, with a low degree of substitution by hydroxypropyl groups. It serves various roles in pharmaceutical formulation, including as a binder and disintegrant in tablet production.

HPMCAS Applications in Pharmaceutical

L-HPC is insoluble in water, but it exhibits swelling properties in this medium. Typical applications of L-HPC include its use as an anti-caking agent, binder, and disintegrant in tablet compression processes, as well as a stabilizer for solid dosage forms.

binder and disintegrant Uquick L-HPC is suitable as a binder and disintegrant for solid dosage forms such as tablets and granules.
Rapid disintegration / rapid dissolution Rapid disintegration breaks down drugs quickly for ingredient release, while rapid dissolution swiftly solubilizes these for faster absorption.
Dry binder for direct compression and wet granulation L-HPC is a versatile binder used in direct compression for its excellent flowability and compressibility, and in wet granulation where it aids in adhesion and structure formation for granule stability.

L-HPC in Orally disintegrating tablet Uquick L-HPC is essential for orally disintegrating tablets, enabling rapid drug release and tablet stability.
L-HPC for Pellet extrusion In pellet extrusion, L-HPC serves as a binder and disintegrant, facilitating the formation of uniform, integral pellets and promoting rapid drug release.
Dispersing aid for capsule filling A dispersing aid in capsule filling helps to evenly distribute the medicinal ingredients, ensuring the correct dosage in each capsule and preventing ingredient aggregation.

Benefits and Applications of L-HPC

Enhancing Drug Delivery with L-HPC

The use of L-HPC in fast-dissolving tablets can optimize the formulation. Its non-ionic nature and absence of peroxides prevent interaction with active pharmaceutical ingredients, thereby enhancing drug stability. The formulation can be simplified by using just one excipient, L-HPC, to ensure tablet hardness and rapid disintegration.

In the process of capsule filling, the swelling properties of L-HPC aid in the disintegration and dissolution of the formed cake. L-HPC possesses various physical and chemical characteristics, making it suitable for different applications. The appropriate grade of L-HPC can be selected by referring to relevant application guides.

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Pharmaceutical Grade Low Substituted-Hydroxypropyl Cellulose (L-HPC)